Posted: 01 Feb 2010 06:29 AM PST

2010-02-01 15:27:07 -

Research and Markets ( www.researchandmarkets.com/research/3ca7b4/g_proteincoupled : ) has announced the addition of John Wiley and Sons Ltd's new report " G Protein-Coupled Receptors: Essential Methods : " to their offering.

G-Protein Coupled Receptors (GPCRs) are not only the largest protein family in the human genome but are also the single biggest target for therapeutic agents. Research into GPCRs is

therefore growing at a fast pace and the range of techniques that can be applied to GPCRs is vast and continues to grow. This book provides an invaluable bench-side guide into the best and most up-to-date techniques for current and future research on GPCRs.

With contributions from leading international authorities, this book equips readers with clear and detailed protocols for both well-known and up-and-coming techniques along with hints and tips for success. All the methods have been tried and tested by leading international research labs and are presented in easy-to-follow stages along with a useful overview of each technique.

This book is an essential resource for all researchers in molecular biology, biochemistry, pharmacology and for graduate students.

Key Topics Covered:

1 Measurement of LigandG-protein-coupled Receptor Interactions Using Radioligand Binding Techniques (Katie Leach, Celine Valant, Patrick M.
Sexton and Arthur Christopoulos).

2 Second Messenger Assays for G-protein-coupled Receptors: cAMP, Ca2+, Inositol Phosphates, ERK1/2 (Karen J. Gregory, Patrick M. Sexton, Arthur Christopoulos and Caroline A. Hick).

3 Use of the [35S]GTPgS Binding Assay to Determine Ligand Efficacy at G-protein-coupled Receptors (Elodie Kara and Philip G. Strange).

4 Quantitative Imaging of Receptor Trafficking (Andy R. James, Takeo Awaji, F. Anne Stephenson and Nicholas A. Hartell).

5 Production of Recombinant G-protein-coupled Receptor in Yeast for Structural and Functional Analysis (Richard A.J. Darby, Mohammed Jamshad, Ljuban Grgic, William J. Holmes and Roslyn M. Bill).

6 Monitoring GPCRProtein Complexes Using Bioluminescence Resonance Energy Transfer (Werner C. Jaeger, Kevin D.G. Pfleger and Karin A.

Eidne).

7 Using Intramolecular Fluorescence Resonance Energy Transfer to Study Receptor Conformation (Cornelius Krasel and Carsten Hoffmann).

8 A Disulfide Cross-linking Strategy Useful for Studying Ligand-induced Structural Changes in GPCRs (Jian Hua Li, Stuart D.C. Ward, Sung-Jun Han, Fadi F. Hamdan and Jrgen Wess).

9 Use of Fluorescence Correlation Spectroscopy to Study the Diffusion of G-protein-coupled Receptors (Stephen J. Briddon, Jonathan A. Hern and Stephen J. Hill).

10 Identification and Proteomic Analysis of GPCR Phosphorylation (Kok Choi Kong, Sharad C. Mistry and Andrew B. Tobin).

11 Measurement and Visualization of G-protein-coupled Receptor Trafficking by Enzyme-linked Immunosorbent Assay and Immunofluorescence (Stuart J. Mundell, Shaista P. Nisar and Eamonn Kelly).

12 Substituted Cysteine Accessibility Method (SCAM) (George Liapakis and Jonathan A. Javitch).

13 Homology Modelling of G-protein-coupled Receptors (John Simms).

For more information visit www.researchandmarkets.com/research/3ca7b4/g_proteincoupled :

Research and MarketsLaura Wood, Senior Manager, press@researchandmarkets.com : mailto:press@researchandmarkets.com U.S.

Fax: 646-607-1907Fax (outside U.S.): +353-1-481-1716

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McGraw-Hill Education Brings Real-World, Contemporary Physics to the ... - Forbes

Posted: 01 Feb 2010 07:48 AM PST

NEW YORK, Feb. 1 /PRNewswire/ -- Physics is a dynamic scientific discipline that strives to find innovative solutions to some of the world's most pressing issues, including the search for alternative energy sources and the development of sustainable technologies. However, unlike texts in fields such as biology and chemistry that incorporate contemporary research into classroom content, many physics textbooks don't focus on modern, real-world examples, leaving students with little exposure to these important and evolving topics. University Physics (McGraw-Hill Higher Education) solves this problem by breaking the mold of traditional physics content, weaving exciting, contemporary ideas and research throughout the text and sharing current advancements and events with students.

By incorporating a variety of contemporary topics and research-based discussions, University Physics helps students understand how physics concepts are related to the development of new technologies in the fields of engineering, medicine (biology), astronomy and more.

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"This text allows students to view physics in a new light," said Kurt Strand, president of McGraw-Hill Higher Education's Science, Engineering and Mathematics Group. "By bringing real-world physics into the classroom, University Physics demonstrates to students just how important this field is to our future."

Written by Dr. Wolfgang Bauer and Dr. Gary Westfall, University Physics was developed by listening to feedback from more than 300 advisors, contributors, manuscript reviewers and focus group participants. In addition, the text was field-tested with approximately 4,000 students in introductory physics classes at Michigan State University.

"I think the approach to include modern or contemporary physics throughout the text is great," said Donna Stokes, Associate Professor and Undergraduate Academic Advisor, University of Houston. "Students often approach physics as a science of concepts, which were discovered long ago. They view engineering as the science that has given them the advances in technology they see today. It's great to show students just where these advances do start, with physics."

The authors' use of University Physics in their own courses showed that incorporating the broad topic of energy engaged their students, encouraging them to formulate and share ideas -- based on real physics concepts -- about how to solve the energy crisis. At Michigan State University, co-author Dr. Bauer has served as a member of the Energy Initiative Coordinating Group and spearheaded an effort to build a carbon-neutral biogas power plant. He was recently invited to serve on an energy expert panel for the U.S. government.

University Physics is supported by the unique web-based assignment and assessment platform McGraw-Hill Connect(TM), the most advanced all-digital teaching and learning exchange for higher education. Connect Physics uses the latest technology and adaptive learning techniques to better engage professors with their students, and students to the information and customized resources they need to master a subject. New interactive tools and problem types developed for Connect Physics, such as the free-body diagram drawing tool and an extensive symbolic/numeric entry palette, allow instructors greater freedom to test conceptual understanding in addition to quantitative skills.

About McGraw-Hill Higher Education:

McGraw-Hill Higher Education, a unit of McGraw-Hill Education, is a premier provider of teaching and learning solutions for 21st century post-secondary and higher education markets worldwide. Through a comprehensive range of traditional and digital education content and tools, McGraw-Hill Higher Education empowers educators and prepares professionals and students of all ages to connect, learn and succeed in the global economy. McGraw-Hill Education, a division of The McGraw-Hill Companies (NYSE: MHP), has offices in 33 countries and publishes in more than 65 languages. Additional information is available at http://www.mheducation.com/.

Contact: Tom Stanton McGraw-Hill Education (212) 904-3214 tom_stanton@mcgraw-hill.com

SOURCE McGraw-Hill Higher Education

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Cells Send Dirty Laundry Home To Mom - Redorbit.com

Posted: 01 Feb 2010 06:51 AM PST

Posted on: Monday, 1 February 2010, 08:56 CST

Understanding how aged and damaged mother cells manage to form new and undamaged daughter cells is one of the toughest riddles of ageing, but scientists now know how yeast cells do it. In a groundbreaking study researchers from the University of Gothenburg, Sweden, show how the daughter cell uses a mechanical "conveyor belt" to dump damaged proteins in the mother cell.

"This ensures that the daughter cell is born without age-related damage," says professor Thomas Nyström from the Department of Cell and Molecular Biology.

Thomas Nyström is a professor of microbiology at the University of Gothenburg and one of Sweden's leading researchers in the field of cellular and molecular biology. His research group has published countless scientific discoveries about cell ageing which have provided a new understanding of aging and age-related diseases. Now he and his colleagues have identified a key piece in the ageing puzzle.

Mechanic transport

In a study published as a feature article in the scientific journal Cell, two collaborating research groups at the Department of Cell and Molecular Biology have been able to show how newly formed yeast cells transport damaged and aged proteins back to the mother cell, guaranteeing that the new cell is born young and healthy.

Mother dustbin

"Previously it was believed that these structures allowed only one-way traffic of proteins and organelles from mother cell to daughter cell," says Nyström. "We can now show that damaged proteins are transported in the opposite direction. In principle, this means that the daughter cell uses the mother cell as a dustbin for all the rubbish resulting from the ageing process, ensuring that the newly formed cell is born without age-related damage."

Conveyor belt

In the study, the researchers show that this transportation is mechanical, using conveyor-like structures called actin cables. A special gene which controls the rate of ageing, called SIR2, is needed for these cables to form properly. Previous research has shown that changing the SIR2 gene can markedly extend the life-span of an organism.

Longer life

"Increased SIR2 activity means a longer life, whereas a damaged SIR2 gene accelerates ageing," says Nyström. "This has been demonstrated in studies of yeast, worms, flies and fish, and may also be the case in mammals."

Future treatment

This knowledge of how age-damaged proteins are transported from daughter cell to mother cell could eventually be used in the treatment of age-related diseases caused by protein toxicity in humans, but Nyström says that it is too early to say how.

The first step

"The first step is to study whether this transportation of damaged proteins also occurs in the cells of mammals, including humans, for example in the formation of sex sells and stem cells."

The article "The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates" was published in Cell on January 22. The study was performed jointly by Thomas Nyström and Julie Grantham's research groups at the Department of Cell and Molecular Biology at the University of Gothenburg. The lead author of the article is Beidong Liu, a postdoctoral researcher in Nyström's group.

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Image Caption: Bright green protein aggregates are transported from the young daughter cell into the larger mother cell using conveyor-like structures called actin cables. Credit: University of Gothenburg

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Bees Can Recognize Human Faces - Scientific American

Posted: 01 Feb 2010 07:05 AM PST

Bees' bread and butter is flowers—there's no reason they should be able to distinguish human faces. But they can.
Back in 2005, Arian Dyer at Monash University showed that bees could identify people who they associated who with sugary snacks. But could they recognize humans, or did they just see them as weird flowers?

Martin Giurfa at France's Université de Toulouse contacted Dyer to work on that question. First, they drew simple images of facial features—dots for eyes, slashes for nose and mouth. The bees were trained to distinguish between an image with narrower features and one with wider ones.

Then the scientists asked if the insects could distinguish facelike features from non-faces? The bees won sugary rewards when they picked out faces as opposed to pictures that just had random dots and dashes.

Finally, the critters faced their ultimate task: to pick out real faces from those that had the features scrambled. And: score. Bees could indeed differentiate faces from non-faces. The study was published in the Journal of Experimental Biology. Scientists hope that the simple bee brain could be a model for automated facial recognition. Which could help in FBI stings.

—Cynthia Graber

[The above text is an exact transcript of this podcast.]

60-Second Science is a daily Podcast. Subscribe to this Podcast: RSS | iTunes

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Monday, February 1, 2010

“Research and Markets: G Protein-Coupled Receptors: Essential Resource ... - PR Inside” plus 3 more

“Research and Markets: G Protein-Coupled Receptors: Essential Resource ... - PR Inside” plus 3 more

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