“Nobel Laureate Claims The 2010 Herbert Tabor Lectureship - Medical News Today” plus 4 more |
- Nobel Laureate Claims The 2010 Herbert Tabor Lectureship - Medical News Today
- Sweet as can be: How E. coli gets ahead - PhysOrg
- Senesco Technologies to present data on its multiple myeloma drug ... - News-Medical.Net
- How E. Coli Gets Ahead - Redorbit.com
- University Events - University of Washington
| Nobel Laureate Claims The 2010 Herbert Tabor Lectureship - Medical News Today Posted: 12 Nov 2009 04:59 AM PST  Main Category: Cancer / Oncology Also Included In: Genetics; Conferences; Biology / Biochemistry Article Date: 12 Nov 2009 - 5:00 PST
Phillip A. Sharp, a world leader of research in molecular biology and biochemistry and an institute professor at the Massachusetts Institute of Technology, has been named winner of the American Society for Biochemistry and Molecular Biology Herbert Tabor/Journal of Biological Chemistry Lectureship. Sharp will give his award lecture, titled "The Biology of small RNAs," at the 2010 annual meeting at 6 p.m. Saturday, April 24, in Anaheim, Calif. Sharp's research interests have centered on the molecular biology of gene expression relevant to cancer and the mechanisms of RNA splicing. His landmark achievement was the discovery of RNA splicing in 1977, for which he shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts. "Phil's work has been characterized by a remarkable creativity -- he has literally broken open whole new fields -- and also by an equally remarkable track record for training outstanding scientists," said ASBMB President Gregory A. Petsko. "I can personally testify to his willingness to help young colleagues and to the generosity with which he has given his time to numerous good causes. He is a shining example of what a senior scientist should be." Currently, Sharp has turned his attention to understanding RNA interference, the process by which RNA molecules act as switches to turn genes on and off. This recently discovered phenomenon has revolutionized biology and could potentially generate a new class of therapeutics. Sharp did his undergraduate studies at Union College in Barbourville, Ky., where he majored in chemistry and mathematics, then completed his Ph.D. in chemistry at the University of Illinois at Urbana-Champaign in 1969, studying under noted physical chemist Victor Bloomfield. While at the University of Illinois, Sharp read the 1966 volume of the Cold Spring Harbor Symposium on Quantitative Biology, titled "The Genetic Code," and became interested in molecular biology and genetics. He subsequently obtained a postdoctoral fellowship at the California Institute of Technology, where he studied the structure of sex factor and drug resistance plasmids in bacteria. In 1971, Sharp began a second postdoc, studying gene expression at the Cold Spring Harbor Laboratory under the renowned James D. Watson. In 1974, Sharp joined MIT's Center for Cancer Research, now known as the David H. Koch Institute for Integrative Cancer Research, and has remained on the MIT campus ever since. He has held numerous leadership positions along the way: He was director of the Center for Cancer Research from 1985 to 1991, head of the biology department from 1991 to 1999 and director of the McGovern Institute for Brain Research from 2000 to 2004. Sharp, who has authored more than 350 scientific papers, has received numerous awards and honorary degrees and has served on advisory boards for the government, academic institutions, scientific societies and companies. His other awards include the Gairdner Foundation International Award, the General Motors Research Foundation Alfred P. Sloan Jr. Prize for Cancer Research, the Albert Lasker Basic Medical Research Award, the National Medal of Science and the inaugural Double Helix Medal from the Cold Spring Harbor Laboratory. Sharp is a member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences and the American Philosophical Society. In addition, Sharp is a co-founder of Biogen (now known as Biogen Idec) and Alnylam Pharmaceuticals. Source: Angela Hopp
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| Sweet as can be: How E. coli gets ahead - PhysOrg Posted: 12 Nov 2009 07:30 AM PST Sweet as can be: How E. coli gets aheadNovember 12, 2009Scientists at the University of York have discovered how certain bacteria such as Escherichia coli have evolved to capture rare sugars from their environment giving them an evolutionary advantage in naturally competitive environments like the human gut. Microbes are well-known for their ability to grow in demanding and nutritionally poor environments, which has allowed them to colonise some of the most remote places on the planet. Bacteria living in theoretically nutrient-rich environments like the mammalian intestine face similar challenges due to intense competition between bacterial species in the intestine for the finite amount of available food. Researchers led by Dr Gavin Thomas in the University's Department of Biology discovered that a protein present in the intestinal bacterium Escherichia coli was a unique sugar transporter. Common sugars like glucose form a cyclic structure called a 'pyranose' when dissolved in water. All transporters for glucose recognise the pyranose form. But, for sugars such as galactose, which is commonly found in dairy produce, around 10 per cent is found in a different ring form called a 'furanose'. Initial work on the unknown E. coli transporter by Dr Thomas's team suggested that it was a galactose transporter. The researchers knew that E. coli has a galactopyranose transporter already, so why should the bacterium have evolved another system to do exactly the same thing? The answer to the problem was discovered when researchers led by Professor Keith Wilson in the York Structural Biology Laboratory solved the 3D structure of the protein, revealing that it was bound to the rarer furanose form of galactose. Experiments by Dr. Jennifer Potts in the University's Centre for Magnetic Resonance confirmed that the transporter was the first biological example to recognise furanose over pyranose forms. Dr Thomas said: "The picture that emerges is that bacteria have evolved many related transporters to allow them to exploit every possible potential source of nutrient in their environment. Being able to use the extra 10 per cent of galactose available in the gut appears a trivial adaptation. But it is exactly the small change required to allow E. coli to grow a little bit faster when galactose is present in the gut, and so persist at the expense of other species of bacteria." The work was published in the Journal of Biological Chemistry. Source: University of York This content has passed through fivefilters.org. | |
| Senesco Technologies to present data on its multiple myeloma drug ... - News-Medical.Net Posted: 12 Nov 2009 07:37 AM PST Senesco Technologies, Inc. ("Senesco" or the "Company") (NYSE Amex: SNT) announced today that Catherine Taylor, one of the Company's funded researchers, will be presenting pre-clinical stability and biological activity data on SNS-01, Senesco's multiple myeloma drug candidate, at the 2009 American Association for Cancer Research (AACR)-National Cancer Institute (NCI)-European Organization for Research and Treatment of Cancer (EORTC) Molecular Targets and Cancer Therapeutics Conference. Ms. Taylor is a member of the Department of Biology at the University of Waterloo, Ontario, Canada. The conference will take place from Sunday, November 15th through Thursday, November 19th, in Boston, MA. Ms. Taylor's abstract will be presented at a session entitled, "Gene Therapies", which will run from 12:30 PM until 2:30 PM on Monday, November 16th. The conference, hosted by AACR, NCI and EORTC, will bring together academics and scientists and representatives from the pharmaceutical industry to discuss innovation in drug development, target selection and the impact of new discoveries in molecular and cell biology. The event has been organized to reflect the many recent advances in the early development of promising new compounds, which are in different levels of preclinical and clinical development. SOURCE Senesco Technologies, Inc. This content has passed through fivefilters.org. | |
| How E. Coli Gets Ahead - Redorbit.com Posted: 12 Nov 2009 07:37 AM PST Posted on: Thursday, 12 November 2009, 09:41 CST Scientists at the University of York have discovered how certain bacteria such as Escherichia coli have evolved to capture rare sugars from their environment giving them an evolutionary advantage in naturally competitive environments like the human gut. Microbes are well-known for their ability to grow in demanding and nutritionally poor environments, which has allowed them to colonize some of the most remote places on the planet. Bacteria living in theoretically nutrient-rich environments like the mammalian intestine face similar challenges due to intense competition between bacterial species in the intestine for the finite amount of available food. Researchers led by Dr Gavin Thomas in the University's Department of Biology discovered that a protein present in the intestinal bacterium Escherichia coli was a unique sugar transporter. Common sugars like glucose form a cyclic structure called a 'pyranose' when dissolved in water. All transporters for glucose recognize the pyranose form. But, for sugars such as galactose, which is commonly found in dairy produce, around 10 per cent is found in a different ring form called a 'furanose'. Initial work on the unknown E. coli transporter by Dr Thomas's team suggested that it was a galactose transporter. The researchers knew that E. coli has a galactopyranose transporter already, so why should the bacterium have evolved another system to do exactly the same thing? The answer to the problem was discovered when researchers led by Professor Keith Wilson in the York Structural Biology Laboratory solved the 3D structure of the protein, revealing that it was bound to the rarer furanose form of galactose. Experiments by Dr Jennifer Potts in the University's Centre for Magnetic Resonance confirmed that the transporter was the first biological example to recognize furanose over pyranose forms. Dr Thomas said: "The picture that emerges is that bacteria have evolved many related transporters to allow them to exploit every possible potential source of nutrient in their environment. Being able to use the extra 10 per cent of galactose available in the gut appears a trivial adaptation. But it is exactly the small change required to allow E. coli to grow a little bit faster when galactose is present in the gut, and so persist at the expense of other species of bacteria." The work was funded through a Biotechnology and Biological Sciences Research Council quota studentship to Dr Richard Horler in the laboratory of Dr Thomas. The research involved Dr Axel Muller, from the laboratory of Professor Wilson, and NMR expertise from David Williamson and Dr Potts. The work was published in the Journal of Biological Chemistry. --- On the Net: This content has passed through fivefilters.org. | |
| University Events - University of Washington Posted: 12 Nov 2009 05:49 AM PST University Events | University Events "University Events" lists a portion of the activities taking place Nov. 12-25 at Washington University. Visit the Web for expanded calendars for the Danforth Campus (news-info.wustl.edu/calendars) and the School of Medicine (medschool.wustl.edu/calendars.html). Exhibits "Metabolic City." Through Jan. 4. Kemper Art Museum. 935-4523. Films
7 p.m. Korean Film Series. "A Shark." Kim Dong-hyun, dir. Seigle Hall, Rm. L004. 935-5110. Lectures 4 p.m. Chemistry Seminar. "Systematic Approaches for Engineering Molecule-Based Magnetic and Photo-Responsive Materials." Stephen Holmes, prof., U. of Mo.-St. Louis. McMillen Lab., Rm. 311. 935-6530. 4 p.m. Developmental Biology Lecture. Annual Oliver H. Lowry Lecture. "MicroRNA Control of Cardiovascular Development and Disease." Eric N. Olson, chair in science, Southwestern Medical Center. Farrell Learning & Teaching Center, Connor Aud. 362-0198. 4:15 p.m. Earth & Planetary Sciences Colloquium. Paul Schenk, staff scientist, Lunar & Planetary Inst. Earth & Planetary Sciences Bldg., Rm. 203. 935-5610. 4:30 p.m. Germanic Languages & Literatures Foreign Language Learning Colloquium Series. "Language Learning in Contemporary Study Abroad." Celeste Kinginger, assoc. prof. of applied linguistics & French, Penn. State U. Co-sponsored by depts. of Asian and Near Eastern Languages & Literatures, Romance Languages & Literatures and Psychology, the Teaching Center and the Dean of the Faculty of Arts & Sciences. Busch Hall, Rm. 100. 935-5110.
9:15 a.m. Pediatric Grand Rounds. "Rethinking Brain Tumors: Lessons From Mouse Models." David Gutmann, prof. of neurology. Clopton Aud., 4950 Children's Place. 454-6006. 11 a.m. Computer Science & Engineering Colloquium. "Gradient-Descent Methods for Temporal-Difference Learning: Active Learning in Regression Over Finite Domains." Csaba Szepesvari, assoc. prof. of computing science, U. of Alberta, Canada. Cupples II Hall, Rm. 217. 935-6160. 11 a.m. Energy, Environmental and Chemical Engineering Seminar Series. "Where Do Cloud Condensation Nuclei Come From?" Peter Adams, assoc. prof. of civil & environmental engineering, Carnegie Mellon U. Lopata Hall, Rm. 101. 935-5548. Noon. Cell Biology & Physiology Lecture. "Animating the Transport Cycle: The Role of Protein Dynamics in Multidrug Resistance Activity of EmrE." Katherine A. Henzler-Wildman, asst. prof. of biochemistry and molecular biophysics. McDonnell Medical Sciences Bldg., Rm. 426. 362-6950. 7 p.m. Center for the Study of Ethics & Human Values Panel Discussion. "Is America Really Post-Racial?" Part of "Ethnic Profiling: A Challenge to Democracy" series. Co-sponsored by Skandalaris Center for Entrepreneurship, African and African American studies, Mo. History Museum, Student Union, campusprogress.org and the Jamestown Project. Danforth University Center, Tisch Commons. For information: humanvalues.wustl.edu.
2:30 p.m. Energy, Environmental and Chemical Engineering Seminar Series. "Genome Engineering for Sustainable Biofuels." Ryan Gill, managing dir., Colo. Center for Biorefining and Biofuels. Co-sponsored by I-CARES. Cupples II Hall, Rm. 200. 935-5548. 4 p.m. Genetics Seminar. Annual Donald C. Shreffler Memorial Lecture. "The Etiology of Type 1 Diabetes." John Todd, principal investigator, Cambridge Inst. for Medical Research, U.K. Co-sponsored by the Dept. of Pathology & Immunology. Moore Aud. 362-2139.
5 p.m. Freedom From Smoking Class. "Quit Day." Center for Advanced Medicine, Barnard Health and Cancer Info. Center. To register: 362-7844. 6 p.m. Women's Society Panel Discussion. "Composing a Life." (Includes appetizers and a networking reception.) Whitaker Hall Aud. & Atrium. To R.S.V.P.: womenssociety.wustl.edu/composingalife.
3:30 p.m. History Colloquium. "Honey, I'm Going to See a Magistrate: Rethinking Women's Political Action in the Nineteenth Century South." Laura Edwards, prof. of history, Duke U. (Reception follows.) Co-sponsored by women, gender and sexuality studies. Busch Hall, Rm. 18. 935-5450. 4 p.m. Siteman Cancer Center Breast Cancer Research Group Seminar Series. "Breast Cancer in Asian-American Women." Anna H. Wu, prof. of preventive medicine, Norris Comprehensive Cancer Center. Center for Advanced Medicine, Farrell Conference Rm. 1. 454-8981. 5 p.m. Kemper Art Museum Gallery Talk. "Ellsworth Kelly and Chance Aesthetics." Tricia Y. Paik, asst. curator, Saint Louis Art Museum. Kemper Art Museum. 935-4523. 5 p.m. School of Medicine Lecture. "Update on 2009 Influenza Pandemic." Alexander Garza, chief medical officer, U.S. Dept. of Homeland Security. Farrell Learning & Teaching Center, Connor Aud. 362-2820.
Noon. Genetics Seminar. "Modeling the Systems Biology of Complex Traits in the Post-GWAS Era." Yves A. Lussier, assoc. prof of genetic medicine, U. of Chicago. McDonnell Medical Sciences Bldg., Rm. 823. 362-2139. 4 p.m. Office of Technology Management Technology Commercialization Seminar Series. "Understanding Translational Research and Funding Opportunities." Farrell Learning and Teaching Center, Connor Aud. 747-0908. 4 p.m. Vision Science Seminar Series. "Damaged Input to Visual Area V1 as the Cause of Crossed-Eyes in Infant Human and Monkey." Lawrence Tychsen, prof. of ophthalmology. Maternity Bldg., Rm. 725. 362-3315. 4:15 p.m. Earth & Planetary Sciences Colloquium. Bethany Ehlmann, Ph.D. candidate in geological sciences, Brown U. Earth & Planetary Sciences Bldg., Rm. 203. 935-5610. 5 p.m. Freedom From Smoking Class. "Recovery and Support." Center for Advanced Medicine, Barnard Health and Cancer Info. Center. To register: 362-7844.
11 a.m. Energy, Environmental and Chemical Engineering Seminar Series. Hai Wang, prof. of aerospace and mechanical engineering, U. of Southern Calif. Lopata Hall, Rm. 101. 935-5548. Noon. Cell Biology & Physiology Lecture. "Biology Without Bias: New Tools for Probing Biological Systems." Jonathan S. Weissman, prof. of cellular and molecular pharmacology, U. of Calif., San Francisco. McDonnell Medical Sciences Bldg., Rm. 426. 362-6950. 4 p.m. Dept. of Music Lecture Series. "Ancient Instruments and Music of Persia." Fardin Karamkhani, luthier, Karamkhani Instruments. Music Classroom Bldg., Rm. 102. 935-5566.
5 p.m. Freedom From Smoking Class. "Stress Management and Weight Control." Center for Advanced Medicine, Barnard Health and Cancer Info. Center. To register: 362-7844. Music 8 p.m. Jazz at Holmes. Miles Davis tribute featuring selections from "In a Silent Way" and "Petit Machins." Ridgley Hall, Holmes Lounge. 862-0274.
Sports 3 p.m. Men's Basketball vs. MacMurray College. Athletic Complex. 935-4705.
On Stage
And More 4 p.m. Faculty Book Colloquium. Lewis Menand, prof. of English, Harvard U. Grahan Chapel. To R.S.V.P.: 935-5576.
11 a.m.-1 p.m. Great American Smokeout. Farrell Learning and Teaching Center and Center for Advanced Medicine, Schoenberg Lobby. 362-7196. 7-11 p.m. Film and Media Studies. Cinematography Workshop. Barry Braverman, cinematographer. Eads Hall, Rm. 013. 935-4056. For a full listing of medical rounds and conferences, see the School of Medicine's Web site. Also, for more events, please see the expanded Danforth Campus calendar Web site. Events sponsored by the University -- its departments, schools, centers, organizations and recognized student organizations -- are published in the calendar. All events are free and open to the public, unless otherwise noted. Calendar submissions should state time, date, place, sponsor(s), title of event or lecture, name(s) of speaker(s), speaker(s) affiliations and admission cost. Mail items to Calendar at Campus Box 1070 or fax to 935-4259 or e-mail at recordcalendar@wustl.edu. Submission forms are available by calling 935-4926 or by downloading the PDF found here. The deadline for all entries is noon on the Thursday seven days before the Record issue date. Late or incomplete entries will not be printed. The Record is published every Thursday during the school year, except holidays, and monthly during the summer.  This content has passed through fivefilters.org. |
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