“Caliper Life Sciences Partners with Prestwick Chemical to Offer ... - Stockhouse” plus 4 more |
- Caliper Life Sciences Partners with Prestwick Chemical to Offer ... - Stockhouse
- NESCent helps to build a global digital data network for biology and ... - Genetic Engineering News
- Evolution institute named for pioneering UW-Madison geneticist - UW Madison
- Biologists And Engineers Decode The Next Frontier - Redorbit.com
- The biology of obsession - The Daily
Caliper Life Sciences Partners with Prestwick Chemical to Offer ... - Stockhouse Posted: 19 Nov 2009 07:00 AM PST --- Caliper Discovery Alliances & Services Offerings Expand to Include Medicinal Chemistry Tools for Lead Compound Optimization - HOPKINTON, Mass., Nov 19, 2009 /PRNewswire-FirstCall via COMTEX News Network/ -- Caliper Life Sciences, Inc. (Nasdaq: CALP), a leading provider of tools and services for drug discovery and life sciences research, today announced a strategic partnership between the company's contract research organization, Caliper Discovery Alliances & Services (CDAS), and Prestwick Chemical (Strasbourg, France) to provide customized outsourced medicinal chemistry and in vitro and in vivo preclinical biology programs for drug discovery research. The non-exclusive co-marketing agreement offers complete chemistry and biology research programs to help pharmaceutical and biotechnology customers increase identification of lead compounds. The outsourcing of medicinal chemistry and biology processes is increasingly strategic as pharmaceutical and biotechnology companies look to reduce costs while accelerating the pace and clinical relevance of drug discovery research. Through Caliper's partnership with Prestwick, drug discovery organizations are now able to contract out comprehensive chemistry, and biology screening and profiling activities, benefiting from Caliper's in vitro and in vivo research capabilities and Prestwick's expertise in medicinal chemistry for hit discovery, hit validation, hit to lead expansion and lead optimization. Clients can quickly screen compounds from the Prestwick Chemical smart libraries through CDAS in a panel of over 1,000 optimized in vitro assays to assess drug property improvement such as selectivity, potency and toxicity. Further hit-to-lead and lead compound optimization can be conducted through customized Caliper - Prestwick collaborations with customers. "Outsourcing complete chemistry-biology research programs answers an industry need for increased productivity, efficiency and turnaround time in the drug development process," said David Manyak, executive vice president, drug discovery services, Caliper Life Sciences. "By providing integrated chemistry and biology programs, researchers now have a unique opportunity to access combined best in class chemistry and preclinical biology research that is invaluable in identifying safe and effective new drug candidates while minimizing commitment of internal resources." CDAS and Prestwick Chemical have collaborated closely since 2004 to develop efficient processes for outsourced research. "Following the joint projects that have been extremely successful for our clients, I am very happy that we are able to confirm our involvement with Caliper and extend this offer to better serve drug discovery companies," said Prof. Camille Wermuth, president and CSO, Prestwick Chemical. About Caliper Life Sciences Caliper Life Sciences is a premier provider of cutting-edge technologies enabling researchers in the life sciences industry to create life-saving and enhancing medicines and diagnostic tests more quickly and efficiently. Caliper is aggressively innovating new technology to bridge the gap between in vitro assays and in vivo results and then translating those results into cures for human disease. Caliper's portfolio of offerings includes state-of-the-art microfluidics, lab automation & liquid handling, optical imaging technologies, and discovery & development outsourcing solutions. For more information please visit www.caliperLS.com About Prestwick Prestwick Chemical, created in 1999 by Prof. Camille G. Wermuth, offers top-notch medicinal chemistry services and brings hit/lead compounds to pre-clinical/clinical studies. These services include hit validation, lead optimization and ligand profiling supported by state of the art computer-aided molecular design and large-scale virtual screening where ADME/T and selectivity issues can be addressed. Prestwick Chemical always delivers smart IP strategies to improve the project's future. Furthermore, Prestwick Chemical offers smart and original screening libraries. Prestwick's laboratories and management are located in Strasbourg, France, at the crossroads of France, Germany and Switzerland and employ a very stable group of experienced medicinal chemists. For more information please visit www.prestwickchemical.com Caliper is a registered trademark of Caliper Life Sciences, Inc. SOURCE Caliper Life Sciences, Inc. http://www.caliperLS.com Copyright (C) 2009 PR Newswire. All rights reservedThis content has passed through fivefilters.org. |
NESCent helps to build a global digital data network for biology and ... - Genetic Engineering News Posted: 19 Nov 2009 08:18 AM PST Nov 19 2009, 11:21 AM EST NESCent helps to build a global digital data network for biology and the earth sciencesEUREKALERT Contact: Dr. Todd Visiontjv@bio.unc.edu 919-843-4508 National Evolutionary Synthesis Center (NESCent) DURHAM, NC - The National Evolutionary Synthesis Center is now part of a major new digital data initiative that will improve the ability of scientists, policymakers and the public to monitor the status of Earth's biota and the environment. Named DataONE (Data Observation Network for Earth), the initiative aims to provide secure and permanent access to data in biology and the earth sciences, including atmospheric, ecological, evolutionary, hydrological, and oceanographic sources. "The goal is to provide access to data that are currently in many different institutions and in many different formats," said Dr. Ryan Scherle, who oversees NESCent's digital data efforts. Dozens of institutions have partnered to make DataONE a reality, including academic and government data centers, research libraries, citizen science programs, and international affiliates. "We have more than ten different repositories that are planning to join the DataONE network," said Scherle. "One of our largest challenges is getting the technology up to speed so that they can all communicate." "NESCent is a natural partner in this ambitious effort," said Dr. Todd Vision, Associate Director of Informatics at NESCent. "Evolutionary research provides unique insights into modern environmental challenges. Historic range expansions can be used to forecast the impacts of invasive species, and past responses of ecosystems to climate change can help us to predict what the range of consequences will be. But first, researchers need to be able to combine data from many different sources. " The initiative is supported by the U.S. National Science Foundation DataNet program, and is headquartered at the University of New Mexico. The project is slated to cost $20M over 5 years. NSF plans to establish five DataNets at this scale, and DataONE is one of the first two that have been funded. The National Evolutionary Synthesis Center (NESCent) is an NSF-funded collaborative research center operated by Duke University, the University of North Carolina at Chapel Hill, and North Carolina State University. For more on the NSF DataNet project, see http://www.nsf.gov/pubs/2007/nsf07601/nsf07601.htm This content has passed through fivefilters.org. |
Evolution institute named for pioneering UW-Madison geneticist - UW Madison Posted: 19 Nov 2009 08:11 AM PST Nov. 19, 2009 A few days before the 150th anniversary of the "Origin of Species," Charles Darwin's epochal book on evolution, plans for a new evolution institute moved closer to final approval at the University of Wisconsin-Madison. On Nov. 18, the College of Letters & Science Academic Planning Council unanimously approved the J.F. Crow Institute for the Study of Evolution, following unanimous approval from a similar body in the College of Agricultural and Life Sciences. The final hurdle will occur when the institute is discussed by the University Academic Planning Council at a meeting scheduled for December. Just as the principle of descent from common ancestry unites the many branches of biology, from the study of individual genes to studies of ecosystems, the evolution institute will knit together more than 70 faculty members strewn across seven colleges on campus, says David Baum, professor of botany and leader of the Evolution Coordinating Committee, which proposed the new institute. UW-Madison is already a powerhouse in biology, Baum notes, but "we need the institute because evolutionary biology has become such an important discipline. It's not appropriate to have a campus of this stature without a department of evolutionary biology, without a graduate program in evolutionary biology and with no other unit focused on evolutionary research and education. Our emphasis on biology is scattered, and we need something that brings people together across all the colleges." The institute will be named for James F. Crow, professor emeritus of genetics, who pioneered mathematical approaches to population genetics and molecular evolution more than a half century ago. Although evolution is often portrayed as "just" a theory, it has become the organizing principle by which scientists make sense of the forms, structures and relationships of organisms on Earth. Evolution is a critical tool in broad use among the many realms of biology, Baum says. "There is an increasing appreciation for the ways in which pathogens and pests evolve, so we need to understand evolution in order to stop, control or respond appropriately. That is what we call applied evolution, which will be one important focus of the institute." Applied evolution can be used to study social problems such as global warming, extinctions of species, invasions of alien species, and threats to livestock and crops. For example, Carol Lee, an associate professor of zoology at UW-Madison's Center of Rapid Evolution, is using evolutionary approaches to study how organisms have invaded the Great Lakes. Most of these invaders came from distant and distinct habitats, she says, and they are adapting to their new circumstances. "Over the last 10 years, people have started discovering that the populations that successfully invade are often different from their ancestors because they have evolved to survive in novel environments." A saltwater animal that invades the Great Lakes must be able to survive in fresh water, and natural selection will favor genes that allow this survival, Lee says. "We can go into the genome and discover which traits are evolving most intensely, and that will reveal the factors that limit their survival. These discoveries may allow us to find their Achilles' heel that could eventually lead to more effective methods for controlling destructive invaders." Evolution is playing a key role in human disease, Baum adds, noting that the development of resistance to antibiotics is a clear example of evolution in action. He adds that if HIV, the cause of AIDS, "does not evolve to evade drugs and the immune system, it would not kill patients." The genetic roots of disease continue to be unraveled, says Bret Payseur, an assistant professor of medical genetics at UW-Madison. "One popular strategy for identifying genes that cause disease is to compare disease status and DNA markers in large groups of people. DNA markers that correlate with disease can point to important genes." Like many other areas in genetics, this approach rests on discoveries by the new institute's namesake, Payseur says. "Ultimately, understanding inherited variation in disease requires understanding variation in DNA, the primary goal of the field of population genetics. And in that field, Jim Crow is a pioneer."
Crow also delighted in teaching large, introductory classes on genetics, and shouldered his share of institutional duties while chairing the Department of Medical Genetics for five years and the Laboratory of Genetics for eight years. "I'm pleased and rather surprised," says Crow, with characteristic humor. "Usually these things are named after a person who has died, but I am not going to take the hint." Although Crow was known for his mathematical approach, "I was only a mediocre mathematician," he says. "I had some very good mathematicians as students. When we wrote things together, they did the heavy mathematical lifting and I posed the problems and did the theory." Crow's main interest was the impact of mutations on populations, but he and his 50-plus graduate students and postdoctoral students ranged widely. "The usual advice to a young professor is to pick something and stick with it," he says. "I did the opposite; it made for a more interesting life, but it's a risky approach." Motoo Kimura, one early graduate student, arrived from Japan shortly after Crow became an assistant professor at UW-Madison in 1948. Kimura, who became a noted geneticist in his own right, developed the concept of "neutral evolution," that most changes in DNA are not subject to natural selection. This analysis became the basis for the "molecular clock," which can determine when two species last shared a common ancestor, one measure of how strongly they are related. Discoveries that Crow made with other graduate students focused on "transposable elements," genes that "jump" about in the chromosomes, and "selfish genes," which evade the normal laws of inheritance by de-activating their alternative gene. A conversation with Crow keeps returning to his many students. "When I think about satisfaction, almost No. 1 is the graduate students," he says. "I tried to accept students who were smarter than I was, and most of the time I succeeded. For the really good ones, my role has been sympathetic listener, rather than guide." The study of genetics and evolution has exploded in the past few decades, and Crow says he sometimes thinks it might be nice to start over. "In a sense, I have been replaced by computers and DNA chemistry. It's very exciting now, but I think the individualism has been lost. So much is done now by teams, and I like to work individually, or with one or two students." Crow, who began studying genetics and evolution before the structure of DNA was even known, says the data glut of recent years has caused a fundamental shift in genetics. "We used to have awfully good theory and not much data. Now we have so much data and not enough theory." This content has passed through fivefilters.org. |
Biologists And Engineers Decode The Next Frontier - Redorbit.com Posted: 19 Nov 2009 08:04 AM PST Posted on: Thursday, 19 November 2009, 10:11 CST A team of Princeton biologists and engineers has dramatically improved the speed and accuracy of measuring an enigmatic set of proteins that influences almost every aspect of how cells and tissues function. The new method offers a long-sought tool for studying stem cells, cancer and other problems of fundamental importance to biology and medicine. The research allows scientists an unprecedented look at a special class of proteins called histones, which are at the core of every chromosome and control the way instructions in DNA are carried out. Despite rapid progress in understanding the information encoded in DNA and genes, scientists have achieved much less insight into the so-called "histone code," which determines why a gene in one cell functions differently than the same gene in another cell. "We take a cutting-edge approach to a field that has been using more or less the same techniques for the past 15 years," said Benjamin Garcia, assistant professor of molecular biology, who supervised the experimental aspects of the study. The technique reduces by a factor of 100 the time it takes to analyze histones, while requiring far less sample material and achieving much more nuanced results than existing methods, said Christodoulos Floudas, the Stephen C. Macaleer '63 Professor in Engineering and Applied Science, who oversaw computational aspects of the research. The researchers published their results in the October issue of Molecular & Cellular Proteomics. Their paper was selected as a "must-read" article in Faculty of 1000 Biology, an online journal that selects the most interesting papers in all biology based on peer opinions. A second paper detailing the computational part of the research appeared in Molecular & Cellular Proteomics this month. Collaborators on the papers also include postdoctoral researcher Nicolas Young and graduate student Mariana Plazas-Mayorca of Garcia's group and graduate students Peter DiMaggio and Richard Baliban of Floudas' group in chemical engineering. Despite carrying identical DNA, all cells in a body aren't identical -- a cell in the kidney looks and functions very differently from one in the brain. What makes this specialization possible is a set of instructions stored outside of genes or DNA -- "epigenetic" information -- that helps each cell adapt to its context. Key players in this process are histones, tiny protein spindles that the 6-foot-long DNA molecule wraps itself around in forming a chromosome. Scientists have long known that histones acquire a variety of small chemical decorations -- small molecules attached here and there along the length of the histone. The type and location of these add-ons can regulate nearby genes. Single modifications are known to turn genes on or off, but what happens when multiple modifications occur in combinations -- the "histone code" -- remains a mystery. "The ability to understand this phenomenon and control it with great precision would be revolutionary to medicine," said Young. Distinguishing between various modified forms of a histone has been challenging because several combinations of different modifications can have nearly the same mass. Indeed, under conventional tests two histones with very different functions could appear identical if they have the same set of modifications but at different locations on the molecule. Before now, efforts to distinguish such subtle differences were extremely difficult and time consuming. "We have now developed the first practical means to do this," said Young. The Princeton team combined physical, chemical and mathematical techniques for separating one histone variation from another. First they passed a mix of various histones through a very thin, long tube containing a specially designed material that causes different histone forms to emerge from the tube at different times over a two- to three-hour period. They then bombarded selected molecules with ions to break them apart and send a flood of data into a computer program for high-throughput analysis. "We may get several thousand sets of such measurements over the course of a single experiment," said DiMaggio. When seemingly similar histones are broken into small fragments, differences in the locations of modifications become more apparent. The computer algorithm -- based on an area of math called integer linear optimization -- repeatedly compares all the fragments until it produces a highly accurate list of modifications and their locations. "To see separation of nearly identical species and identify and quantify them with high confidence is very exciting," said Young. He also noted that of the many millions of combinations of modifications possible only a few hundred actually appear in real human cells. This observation implies that combinations of these relatively few modifications form a code that can now be deciphered. The next step will be to link specific patterns of modifications with observable changes in cells. For example, when normal cells transform themselves into cancerous cells, scientists could track the corresponding changes in the histones. Similarly, scientists could identify particular histone codes that are required for stem cells to change into specific tissue types, such as nerve cells or insulin-producing cells. Understanding and potentially reprogramming these processes could have important implications for regenerative medicine, cancer and other diseases. As a start, the researchers are collaborating with biologists from the University of California- Los Angeles to identify histone codes relevant for stem cell behavior. "We've shown we can measure modified histone forms, but there's so much to do now," said Garcia. "This is really the beginning of some true biological breakthroughs." The work was supported by the American Society for Mass Spectrometry, the National Science Foundation, the National Institutes of Health and the Environmental Protection Agency. The National Science Foundation recently awarded a grant of $1.3 million to Floudas, Garcia and Joshua Rabinowitz, associate professor in the Department of Chemistry and the Lewis-Sigler Institute for Integrative Genomics, to develop the techniques into a generalized platform for the analysis of proteins and other biomolecules. --- On the Net: This content has passed through fivefilters.org. |
The biology of obsession - The Daily Posted: 18 Nov 2009 06:21 PM PST Gossip has been around probably since we learned to talk, but the urge to obsess over celebrities is something that is still fairly new. With the deaths of multiple celebrities this summer, attention to the popularity these people have and why so much emphasis has been put into their lifestyles has increased. It is more convenient than ever to find someone to gossip with. "Everyone knows who [celebrities] are, so that automatically displays them as being popular," Johnson said. "People are really trying to live the way that they see life on TV. We idolize things that we see because it's a trend. It's the thing to do." Sometimes, it is an attraction to these individuals that captivates the attention of viewers; they portray the alpha figures of society. It may also be that regular people desire to live like the rich and famous, or even just the need to fit in. LeiLani Nishime, an assistant professor in the Department of Communication, believes that stars are a way for the population, as a culture, to work out anxieties. Celebrities who don't fit into neat categories are the ones that are focused on. "As a culture, we might ask what motherhood looks like," Nishime said. "So, [we] look to people like Britney Spears. She's sexy. She drives without a seatbelt. We look at her to work through what motherhood looks like or what it isn't. Even Michael Jackson was a lightning rod for many issues." Psychology professor David Barash has studied biological adaptation in non-human primates and believes obsession with these public figures is more than just a crush or a feeling of being included. He believes that our sense of community is something that is biologically programmed into each individual and that humans have adapted to societal growth to treat celebrities as leaders and to maintain connections. "It is biologically adapted, in a certain way, to have concern for the dominant individual," Barash said. "Highly social species develop 'local cultures,' such as characteristic vocalization patterns, ways of obtaining food and so forth, which are then passed around among members largely by individuals watching each other. This involves paying particular attention to the dominant individuals and often mimicking them." The focus on prominent individuals is hard-wired into the human system because there is a natural instinct to look for an example of how to live. Celebrity lives are so public that it is easy to use them as role models. They are a focal point in a society that has grown so large that it is impossible to keep track of every person. To compensate, members of society check in on celebrities in the same way their would their closest friends. Barash believes that gossip has taken the place of these local cultures, and, through obsessions, humans metaphorically groom and mimic celebrities. "Their actions show us how we can improve our own status, and in some aspects, how to ruin it," said Nicole Zarfos, a sophomore interested in celebrity attention. However, the ability to decide how a celebrity should be portrayed to the public eye is in the hands of the media. They determine what is important and what we are reading about in People or Us Weekly or watching on cable TV. "Celebrity culture grew up with media," Nishime explained. "They've been around since the beginning of the century. What they do gets multiplied and distributed. The fact that someone in Hollywood can do something and it gets repeated creates a national discussion." If the public is not concerned with a particular celebrity, the media will not highlight that individual. If the dominant individual was not important to human nature, then celebrities would not exist. Their professional careers are only a pathway through which these individuals receive attention. How they lead their personal lives, Barash said, influences society much more because the relatively subordinate individuals look up to them. "The attention structure and who watches whom is important to note," Barash said. "By watching dominant and prominent individuals, the inconspicuous public may gain clues as to how to improve their own dominance status by imitating what the more successful individuals do. Needless to say, this tendency can be exaggerated to unhealthy levels." Humans are creatures of habit, and because of this, attention to celebrities will remain prominent in society. The life of comfort and of leisure is something that the rest of the world will strive for. To a degree, each person — like Johnson and her roommates — is biologically predisposed to focus on dominant individuals. They provide examples of how to lead our own lives. The modern adaptation is an obsession with celebrities, and through the gossip and discussion that is being created about these individuals, a national sense of identity and community has been born. "Celebrity obsessions are a way for us to work out our problems as a group," Nishime said. "It creates a sense of national identity. These celebrities represent our culture, so following along with them helps us feel a part of American culture." Reach contributing writer Mary Jean Spadafora at lifestyles@dailyuw.com. This content has passed through fivefilters.org. |
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