“TRADE NEWS: Institute for Systems Biology, Agilent Technologies to ... - MSN Money” plus 4 more |
- TRADE NEWS: Institute for Systems Biology, Agilent Technologies to ... - MSN Money
- New CAO offers for 44 students - Irish Times
- Harvard scientists bend nanowires into 2-D and 3-D structures - EurekAlert
- Museum director meets Fairbanks community - KTUU
- genOway Licenses Flex Technology for Creating Inducible Animal ... - Genetic Engineering News
| TRADE NEWS: Institute for Systems Biology, Agilent Technologies to ... - MSN Money Posted: 21 Oct 2009 07:58 AM PDT The Institute for Systems Biology (ISB) and Agilent Technologies Inc. A today announced a collaboration to create the Human Multiple Reaction Monitoring (MRM) Atlas, a comprehensive resource designed to enable scientists to perform quantitative analysis of all human proteins. The project is expected to fuel important research gains in biomarker discovery and validation, the search for protein-based diagnostic tests, personalized medicine, and human health monitoring. The program is supported by grants totaling $4.6 million to ISB's Robert Moritz and Leroy Hood for developing the "Complete Human Peptide and MRM Atlas" by the National Human Genome Research Institute of the National Institutes of Health, under "The American Recovery and Reinvestment Act – Grant Opportunities." Ruedi Aebersold of the Swiss Federal Institute of Technology (ETH) Zurich is collaborating as well, with additional funding from the European Research Council. The work, occurring over two years, will be performed using Agilent triple quadrupole and quadrupole time-of-flight liquid chromatography/mass spectrometry (LC/MS) systems and nanoflow HPLC-Chip/MS systems at ISB in Seattle and at ETH Zurich. "We believe this will be a revolutionary development in protein analysis," said Rob Moritz, ISB faculty member and director of Proteomics, "one that will accelerate and catalyze the routine use of protein quantitation for immensely important breakthroughs in the understanding, early detection and monitoring of human disease." "Agilent is pleased to share leadership in creating the Human MRM Atlas and MRM-based methods to support quantitative protein research," said Ken Miller, Agilent director of LC/MS marketing. "The combination of our triple quadrupole instrumentation, software tools specific for protein analysis, and unique HPLC-Chip/MS technologies creates a stable, sensitive platform for the analysis of these large sample sets." The MRM Atlas is designed to enable scientists to quantitatively access the approximately 20,000 proteins in human tissues, cell lines and blood, potentially transforming many areas of human health research. The project will produce a database of up to four peptides per human protein-coding gene, with verified rapid and accurate MRM-based mass spectrometric assays to enable the unambiguous identification and quantification of almost any protein in the human proteome. It is expected to benefit general biology research and large-scale proteomic studies. About Agilent Technologies Agilent Technologies Inc. A is the world's premier measurement company and a technology leader in communications, electronics, life sciences and chemical analysis. The company's 18,000 employees serve customers in more than 110 countries. Agilent had net revenues of $5.8 billion in fiscal 2008. Information about Agilent is available on the Web at www.agilent.com. About the Institute for Systems Biology The Institute for Systems Biology (ISB) is an internationally renowned, non-profit research institute headquartered in Seattle and dedicated to the study and application of systems biology. Founded by Leroy Hood, Alan Aderem and Ruedi Aebersold, ISB seeks to unravel the mysteries of human biology and identify strategies for predicting and preventing diseases such as cancer, diabetes and AIDS. ISB's systems approach integrates biology, computation and technological development, enabling scientists to analyze all elements in a biological system rather than one gene or protein at a time. Founded in 2000, the Institute has grown to 14 faculty and more than 250 staff members; an annual budget of more than $35 million; and an extensive network of academic and industrial partners. For more information about ISB, visit www.systemsbiology.org. NOTE TO EDITORS: Further technology, corporate citizenship and executive news is available on the Agilent news site at www.agilent.com/go/news. Institute for Systems Biology Copyright 2009 Business Wire This content has passed through fivefilters.org. |
| New CAO offers for 44 students - Irish Times Posted: 21 Oct 2009 05:57 AM PDT Last Updated: Wednesday, October 21, 2009, 13:48PAMELA NEWENHAM Some 44 students will be offered new third-level courses after changes in the marking scheme of the Leaving Certificate biology paper led to an upgrade in results. More than 600 students had their Leaving Certificate biology results upgraded following a review of the marking scheme by the State Examinations Commission (SEC). The SEC decided to revise the marking scheme of the higher level examination paper on foot of an issue raised during the examinations appeal process. The revised marking scheme broadened the range of acceptable answers to a question which was valued at 3 marks out of a total of 400 marks for the subject. The SEC said 621 students had their results upgraded, with the upgrade resulting in a change in offer of a college place for 44 students. Some 20,101 students sat the higher level biology paper last June. This content has passed through fivefilters.org. |
| Harvard scientists bend nanowires into 2-D and 3-D structures - EurekAlert Posted: 21 Oct 2009 07:01 AM PDT ![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small} Public release date: 21-Oct-2009[ | E-mail |  Share ] Contact: Steve Bradt New 'stereocenters' introduce triangular joints into otherwise linear nanomaterialsCAMBRIDGE, Mass., Oct. 21, 2009 -- Taking nanomaterials to a new level of structural complexity, scientists have determined how to introduce kinks into arrow-straight nanowires, transforming them into zigzagging two- and three-dimensional structures with correspondingly advanced functions. The work is described this week in the journal Nature Nanotechnology by Harvard University researchers led by Bozhi Tian and Charles M. Lieber. Among other possible applications, the authors say, the new technology could foster a new nanoscale approach to detecting electrical currents in cells and tissues. "We are very excited about the prospects this research opens up for nanotechnology," says Lieber, Mark Hyman, Jr. Professor of Chemistry in Harvard's Faculty of Arts and Sciences. "For example, our nanostructures make possible integration of active devices in nanoelectronic and photonic circuits, as well as totally new approaches for extra- and intracellular biological sensors. This latter area is one where we already have exciting new results, and one we believe can change the way much electrical recording in biology and medicine is carried out." Lieber and Tian's approach involves the controlled introduction of triangular "stereocenters" -- essentially, fixed 120 joints -- into nanowires, structures that have previously been rigidly linear. These stereocenters, analogous to the chemical hubs found in many complex organic molecules, introduce kinks into 1-D nanostructures, transforming them into more complex forms. The researchers were able to introduce stereocenters as nanowires self-assembled. They halted growth of the 1-D nanostructures for 15 seconds by removing key gaseous reactants from the chemical brew in which the process was taking place, replacing these reactants after joints had been introduced into the nanostructures. This approach resulted in a 40 percent yield of bent nanowires, which can then be purified to achieve higher yields. "The stereocenters appear as 'kinks,' and the distance between kinks is completely controlled," says Tian, a research assistant in Harvard's Department of Chemistry and Chemical Biology. "Moreover, we demonstrated the generality of our approach through synthesis of 2-D silicon, germanium, and cadmium sulfide nanowire structures." The research by Lieber and Tian is the latest in a years-long effort by scientists to control the composition and structure of nanowires during synthesis. Despite advances in these areas, the ability to control the design and growth of self-assembling nanostructures has been limited. Lieber and Tian's work takes the formation of 2-D nanostructures a step further by enabling the introduction of electronic devices at the stereocenters. "An important concept that emerged from these studies is that of introducing functionality at defined nanoscale points for the first time -- in other words, nanodevices that can 'self-label,'" Lieber says. "We illustrated this novel capability by the insertion of pn diodes and field-effect transistors precisely at the stereocenters." Such self-labeled structures could open up the possibility of introducing nanoelectronics, photodetectors, or biological sensors into complex nanoscale structures. Lieber and Tian's co-authors are Ping Xie and Thomas J. Kempa of Harvard's Department of Chemistry and Chemical Biology and David C. Bell of Harvard's Center for Nanoscale Systems. Their work was funded by the National Institutes of Health, the McKnight Foundation, the MITRE Corporation, and the National Science Foundation. [ | E-mail | Share ]
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| Museum director meets Fairbanks community - KTUU Posted: 21 Oct 2009 08:48 AM PDT Associated Press - October 21, 2009 11:54 AM ET FAIRBANKS, Alaska (AP) - The new director of the University of Alaska Museum of the North was formally welcomed Tuesday night at a two-hour reception. Carol Diebel arrived in Fairbanks from New Zealand, where she the director of natural environment at a museum in Wellington. Diebel replaces Aldona Jonaitis, who had been director since 1993. Diebel will also serve as a professor of marine biology in the University of Alaska Fairbanks School of Fisheries and Ocean Sciences. Information from: Fairbanks Daily News-Miner, http://www.newsminer.com Copyright 2009 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed. This content has passed through fivefilters.org. |
| genOway Licenses Flex Technology for Creating Inducible Animal ... - Genetic Engineering News Posted: 21 Oct 2009 08:27 AM PDT Oct 21 2009, 11:15 AM EST genOway Licenses Flex Technology for Creating Inducible Animal MutationsGEN News Highlights genOway obtained an exclusive license to the Flex technology from the Institute of Genetics and Molecular and Cellular Biology for creating inducible mutations in animals. The firms claim that the technology is unique in its ability to create inducible mutations at precise time points. "This technology is very important for the development of even more predictive animal models," comments Alexandre Fraichard, Ph.D., genOway CEO. "It can mimic the appearance of mutations and, therefore, help the consequences of this for biological and pathological (or not) processes to be understood." genOway is dedicated to the development of genetically modified animal models. In February the company commercially launched its new production technology, StemCellHY, for the creation of genetically modified rodents. StemCellHY involves a technology for gene targeting, which genOway reports reduces production costs for this step by 66%. The company suggests the process also reduces the overall time needed to develop specific models by some 20%. The StemCellHY technology uses a bank of rodent embryonic pluripotent stem cell lines acquired by genOway from ThromboGenics. The bank includes embryonic stem cells in new genetic backgrounds, which the company says will enable it to expand its range of animal models. To this end, genOway anticipates the launch of new models specifically for metabolic and inflammatory diseases by mid-2010.
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